TCEP-HCl; Tris (2-carboxymethyl) phosphine-HCl

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SKU: 786-030-XX Category:
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TCEP is a water-soluble, odorless, non-toxic and stable protein reductant. This potent reducing agent is a popular alternative to ß-mercaptoethanol and DTT (dithiothreitol) use for most applications. The reduction potency of TCEP is twice as high as that of DTT, and TCEP is effective in reducing proteins over a wider range of pH conditions, including lower acidic pH ranges (pH 2-11), compared to other reductants.


Since TCEP is a charged molecule, it cannot penetrate hydrophobic environments. Therefore, the use of a denaturant, acidic condition (pH 2.8-5) or basic condition (pH 9-11), is recommended for effective reduction.


TCEP reduces stable disulfide bonds in less than 5 minutes at room temperature and is compatible with the protein alkylation reactions.


For more reducing agents, click here. for TCEP Reducing Gel



  • Chemical Name: tris(2-carboxyethyl)phosphine, HCl
  • Synonym: TCEP, Hydrochloride
  • CAS Number: 51805-45-9
  • Chemical Formula: C₉H₁₅O₆P•HCl
  • Molecular Weight: 286.65
  • Form: White crystalline solid
  • Solubility: Hâ‚‚O (5mg/ml)



  • Reduction of protein and peptide solutions



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